Author Archives: cbhi

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Aug 16, 2019
Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1    Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico   Abstract   Autism is a severe developmental disorder, whose pathogenetic underpinnings are […]

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Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways

Aug 16, 2019
Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways

Biochimica et Biophysica Acta (BBA) – Molecular Cell Research Volume 1865, Issue 11, Part B, November 2018, Pages 1718-1732 Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways☆ Author links open overlay panelRachel L.NguyenabYuliya V.MedvedevaabdTejasvi E.AyyagariabGalinaSchmunkbJohn JayGargusabc a Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA b […]

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Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study

Aug 16, 2019
Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study

Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study Jacquelaine Bartlett, MS,#1 Irene M. Predazzi, PhD,#2 Scott M. Williams, PhD,1 William S. Bush, PhD, MS,3Yeunjung Kim, MD, MPH,4 Stephen Havas, MD, MPH, MS,5 Peter P. Toth, MD, PhD,6 Sergio Fazio, MD, PhD,2 andMichael Miller, MD7     Abstract Background— While the inverse association between high-density lipoprotein […]

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HDL cholesterol and bone mineral density: Is there a genetic link?

Aug 16, 2019
HDL cholesterol and bone mineral density: Is there a genetic link?

HDL cholesterol and bone mineral density: Is there a genetic link? Cheryl L. Ackert-Bicknell   Abstract Overwhelming evidence has linked cardiovascular disease and osteoporosis, but the shared root cause of these two diseases of the elderly remains unknown. Low levels of high-density lipoprotein cholesterol (HDL) and bone mineral density (BMD) are risk factors for cardiovascular […]

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Calcium aids chromosome condensation prior to cell division

Aug 16, 2019
Calcium aids chromosome condensation prior to cell division

Science News from research organizations Calcium aids chromosome condensation prior to cell division Date: December 27, 2016 Source: Osaka University Summary: New research reveals role for calcium ions in chromosome condensation during mitosis; high-resolution imaging of living cells reveals compact, globular chromosomes in the presence of calcium that became fibrous and expand in its absence. […]

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Cancer-Related Hypercalcemia

Aug 7, 2019
Cancer-Related Hypercalcemia

University of Nebraska Medical Center, Omaha, NE Abstract Hypercalcemia has been reported to occur in up to30%of patients whohave a malignancy. Hypercalcemia is most common in those who have later-stage malignancies and predicts a poor prognosis for those with it. The most common causes include humoral hypercalcemia of malignancy mediated by parathyroid hormone–related peptide, osteolytic […]

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Modeling and Analysis of Calcium Signaling Events Leading to Long-Term Depression in Cerebellar Purkinje Cells

Feb 4, 2019
Modeling and Analysis of Calcium Signaling Events Leading to Long-Term Depression in Cerebellar Purkinje Cells

Nicholas Hernjak, Boris M. Slepchenko, Kathleen Fernald, Charles C. Fink, Dale Fortin, Ion I. Moraru, James Watras, and Leslie M. Loew Center for Cell Analysis and Modeling, University of Connecticut Health Center, armington, Connecticut Abstract Modeling and simulation of the calcium signaling events that precede long-term depression of synaptic activity in cerebellar Purkinje cells are […]

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Role of Residual Calcium in Synaptic Depression and Posttetanic Potentiation: Fast and Slow Calcium Signaling in Nerve Terminals

Feb 4, 2019
Role of Residual Calcium in Synaptic Depression and Posttetanic Potentiation: Fast and Slow Calcium Signaling in Nerve Terminals

Dieter Swandulla,+ Michael Hans,+ Karl Zipser,+* and George J. Augustine+5 *Max-Planck-lnstitut fur Biophysikalische Chemie Am Fassberg D-3400 Gottingen Germany +Marine Biological Laboratory Woods Hole, Massachusetts 02543 SDepartment of Neurobiology Duke University Medical Center Durham, North Carolina 27710 Summary Trains of action potentials evoked rises in presynaptic Ca2+ concentration ([Caz+jJ at the squid giant synapse. These […]

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Early pre- and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice

Feb 4, 2019
Early pre- and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice

Shreaya Chakroborty, Joyce Kim, Corinne Schneider, Christopher Jacobson, Jordi Molgó, and Grace E. Stutzmann1. Department of Neuroscience, Rosalind Franklin University / The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 600642. CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie et Développement, UPR 3294, 91198 Gif-sur-Yvette Cedex, France Abstract Alzheimer’s disease (AD)-linked […]

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