Guanyu Hao, Zhi Ping Xu* and Li Li * Abstract
Manipulating extracellular tumour pH: an effective target for cancer therapy
Tag Archives: Tumor
Uncoupling the Warburg effect from cancer
Ayaz Najafov and Dario R. Alessi1 Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland A remarkable trademark of most tumors is their ability to break down glucose by glycolysis at a vastly higher rate than in normal tissues, even when oxygen is copious. This phenomenon, known […]
Glutamine and Cancer
Wiley W. Souba, M.D., Sc.D. From the Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Objective This overview on glutamine and cancer discusses the importance of glutamine for tumor growth, summarizes the alterations in interorgan glutamine metabolism that develop in the tumor-bearing host, and reviews the potential […]
Evaluate SAC Calcium on two dosing schedules for tumor growth inhibition (TGI)
– in the COLO 205 human colorectal adenocarcinoma nude mouse xenograft model NTS Research contracted Charles River Discovery Services North Carolina (CR Discovery Services) to evaluate SAC Calcium on two dosing schedules for tumor growth inhibition (TGI) in the COLO 205 human colorectal adenocarcinoma nude mouse xenograft model. In the Colo205-e347 study, SAC Calcium […]
Calcium electroporation in three cell lines
a comparison of bleomycin and calcium, calcium compounds, and pulsing conditions Stine Krog Frandsen a, Hanne Gissel b, Pernille Hojman c, Jens Eriksena, d, Julie Gehl a,⁎ Abstract Background: Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellular death. In the clinical setting, the cytotoxic drug bleomycin is currently used with electroporation (electrochemotherapy) […]
Direct Therapeutic Applications of Calcium Electroporation to Effectively Induce Tumor Necrosis
Stine Krog Frandsen1, Hanne Gissel2, Pernille Hojman3, Trine Tramm4, Jens Eriksen1,5, and Julie Gehl1 Abstract Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that permits passage of otherwise nonpermeating ions and molecules. In this study, we illustrate how lectroporation with isotonic calcium can achieve highly effective cancer cell kill […]