Andrew P. Landstrom, Dobromir Dobrev and Xander H.T. Wehrens Abstract There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca 2+ ) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, […]
Rebecca A. Capel and Derek A. Terrar Abstract Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of calcium from the sarcoplasmic reticulum (SR) (“calcium clock”). Here we discuss recent evidence on mechanisms […]
Makarand Deo1, Seth H Weinberg2 and Patrick M Boyle3 1Department of Engineering, Norfolk State University, Norfolk, VA, USA. 2Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA. 3Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. AIMS AND SCOPE This Special Collection will gather all studies highlighting recent advances in […]