Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis*

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis*

D.J. Cooper 1, K.R. Walley, P.M. Dodek, E Rosenberg and J.A. Russell 1Program of Critical Care Medicine, St. Paul’s Hospital and University of British Columbia, Vancouver BC, Canada V6ZIY6 Received: 31 May 1991; accepted: 5 February 1992   Abstract. Plasma ionized calcium [Ca § ] concentrations are decreased in patients having lactic acidosis. To further investigate […]

Glucose Metabolism, Lactate, and Ammonia Production by the Human Placenta In Vitro

Glucose Metabolism, Lactate, and Ammonia Production by the Human Placenta In Vitro

IAN R. HOLZMAN, ANTHONY F. PHILIPPS, AND FREDERICK C. BATTAGLIA’27’ Division of Perinatal Medicine, Departments of Pediatrics, and Obstetrics and Gynecology, University of Colorado Medical Center, Denver, Colorado, USA   Summary Fifteen human placentas were obtained at term. Placental fragments were incubated in a bicarbonate-buffered Earle’s solution. Additions of glutamate (1 mM) or glutamine (1 […]

Lactate: Mirror and Motor of Tumor Malignancy

Stefan Walenta and Wolfgang F. Mueller-Klieser   A number of studies have shown that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular  excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagnosis of the disease, we […]