By Steve Edelson, Executive Editor Ammonia has long been viewed as a toxic cellular by-product of glutamine metabolism that has little or no functionality. New findings by a group at Pfizer Inc. now suggest this may not always be the case. The team found that in tumors, ammonia functions as a diffusible signal that […]
T Otsuki1, O Yamada2, H Sakaguchi1, T Ichiki3, K Kouguchi3, H Wada2, H Hata4, Y Yawata2 and A Ueki1 1 Department of Hygiene, 2 Division of Hematology, 3 Department of Clinical Laboratory, Kawasaki Medical School, Kurashiki, Okayama; and 4 The Second Department of Internal Medicine, Kumamoto University School of Medicine, Kummamoto, Japan It is […]
![[¹³N] Ammonia Positron Emission Tomographic/Computed Tomographic Imaging Targeting Glutamine Synthetase Expression in Prostate Cancer](https://cbhi.info/wp-content/uploads/2018/02/GS-6--150x150.jpg)
Xinchong Shi, Xiangsong Zhang, Chang Yi, Yubo Liu, and Qiao He Abstract The purpose of this study was to investigate the expression of glutamine synthetase (GS) in prostate cancer (PCa) and the utility of [¹³N]ammonia positron emission tomography/computed tomography (PET/CT) in the imaging of PCa. The uptake ratio of [¹³N]ammonia and the expression of […]
activity supports cancer cell proliferation under glutamine depletion Yukiko Takeuchi ² , Yasumune Nakayama b, c , Eiichiro Fukusaki b, Yasuhiro Irino a, d, * a The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan b Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 […]
IAN R. HOLZMAN, ANTHONY F. PHILIPPS, AND FREDERICK C. BATTAGLIA’27’ Division of Perinatal Medicine, Departments of Pediatrics, and Obstetrics and Gynecology, University of Colorado Medical Center, Denver, Colorado, USA Summary Fifteen human placentas were obtained at term. Placental fragments were incubated in a bicarbonate-buffered Earle’s solution. Additions of glutamate (1 mM) or glutamine (1 […]
William T. Chance, Lequn Cao, Teri Foley-Nelson, Jeffrey L. Nelson and Josef E. Fischer Department of Surgery, University of Cincinnati Medical Center and Veterans Administration Medical Center, Cincinnati, OH (U.S.A.) (Accepted 11 October 1988) Keywords: Cancer; Anorexia; Ammonia; Amino acid; Neurotransmitter Plasma concentrations of ammonia were elevated significantly in tumor-bearing rats prior to the […]