Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,*   ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]

Calcium signalling and cancer cell growth

Calcium signalling and cancer cell growth

T. CAPIOD1, Y. SHUBA2, R. SKRYMA1 and N. PREVARSKAYA1 1INSERM U800, Laboratoire de Physiologie Cellulaire, Universit√© des Sciences et Technologies Lille 1, 59655 Villeneuve d’Ascq Cedex, France 2Bogomoletz Institute of Physiology, NASU, Bogomoletz Str, 4, 01024 Kiev-24, Ukraine   Abstract Cancer is caused by defects in the mechanisms underlying cell proliferation and cell death. Calcium […]

Glutamate production from ammonia via glutamate dehydrogenase 2

Glutamate production from ammonia via glutamate dehydrogenase 2

activity supports cancer cell proliferation under glutamine depletion   Yukiko Takeuchi ¬≤ , Yasumune Nakayama b, c , Eiichiro Fukusaki b, Yasuhiro Irino a, d, * a The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan b Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 […]