Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,*   ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]

Calcium signalling and cancer cell growth

Calcium signalling and cancer cell growth

T. CAPIOD1, Y. SHUBA2, R. SKRYMA1 and N. PREVARSKAYA1 1INSERM U800, Laboratoire de Physiologie Cellulaire, Université des Sciences et Technologies Lille 1, 59655 Villeneuve d’Ascq Cedex, France 2Bogomoletz Institute of Physiology, NASU, Bogomoletz Str, 4, 01024 Kiev-24, Ukraine   Abstract Cancer is caused by defects in the mechanisms underlying cell proliferation and cell death. Calcium […]

Glutamate production from ammonia via glutamate dehydrogenase 2

Glutamate production from ammonia via glutamate dehydrogenase 2

activity supports cancer cell proliferation under glutamine depletion   Yukiko Takeuchi ² , Yasumune Nakayama b, c , Eiichiro Fukusaki b, Yasuhiro Irino a, d, * a The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan b Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 […]