Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]
Teneale A. Stewart, Kunsala T.D.S. Yapa, Gregory R. Monteith Abstract It is the nature of the calcium signal, as determined by the coordinated activity of a suite of calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell’s fate. Deregulation of the calcium signal is often deleterious and has been linked to each […]
Guanyu Hao, Zhi Ping Xu* and Li Li * Abstract
A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.
Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,* ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]
University of Nebraska Medical Center, Omaha, NE Abstract Hypercalcemia has been reported to occur in up to30%of patients whohave a malignancy. Hypercalcemia is most common in those who have later-stage malignancies and predicts a poor prognosis for those with it. The most common causes include humoral hypercalcemia of malignancy mediated by parathyroid hormone–related peptide, osteolytic […]
Eva C. Schwarz, Bin Qu, Markus Hoth ⁎ Department of Biophysics, Saarland University, Homburg, Germany Article info. Article history: Received 22 September 2012 Received in revised form 16 November 2012 Accepted 18 November 2012 Available online 3 December 2012 Abstract Killing cancer cells by cytotoxic T lymphocytes (CTL) and by natural killer (NK) cells is […]
By Steve Edelson, Executive Editor Ammonia has long been viewed as a toxic cellular by-product of glutamine metabolism that has little or no functionality. New findings by a group at Pfizer Inc. now suggest this may not always be the case. The team found that in tumors, ammonia functions as a diffusible signal that […]
Ayaz Najafov and Dario R. Alessi1 Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland A remarkable trademark of most tumors is their ability to break down glucose by glycolysis at a vastly higher rate than in normal tissues, even when oxygen is copious. This phenomenon, known […]
RJ DeBerardinis1,2 and T Cheng1 1 Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA and 2 McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA Several decades of research have sought to characterize tumor cell metabolism in the hope […]