A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.
Carlotta Giorgi1,, Massimo Bonora1,, Sonia Missiroli1, Federica Poletti1, Fabian Galindo Ramirez2,3, Giampaolo Morciano1, Claudia Morganti1, Pier Paolo Pandolfi4,Fabio Mammano2 and Paolo Pinton1 1 Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biologyand LTTA center, University of Ferrara, Ferrara, Italy 2 Department of Physics and Astronomy, University of Padua, and Venetian […]
Haihong Yang, Qi Zhang, Jianxing He, Wenju Lu State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, PR China ABSTRACT Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous cellular signal, which is crucial in cancer. This review presents regulation of calcium […]
Stefan Walenta and Wolfgang F. Mueller-Klieser A number of studies have shown that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagnosis of the disease, we […]
Master of Science Thesis VT2016 -Jessica Billberg Introduction Calcium is an important ubiquitous second messenger regarding the maintenance of cellular homeostasis, and is therefore tightly regulated. Calcium induces cell death when internalised into cancer cells after permeabilization of the cell membrane by electroporation. It is established that radiation causes damage to the lipids and proteins […]