A longitudinal Study of the effect of sodium and calcium intakes on regional bone densityof postmenopausal women

A longitudinal Study of the effect of sodium and calcium intakes on regional bone densityof postmenopausal women

Amanda Devine, R Arthur Criddle, Ian M Dick, Deborah A Kerr, and Richard L Prince Abstract The influence of urinary sodium excretion and dietary calcium intake was examined in a 2-y longitudinal study of bone density in 124 women postmenopausal for > 10 y. Analysis of bone density changes showed that urinary sodium excretion was […]

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

So-Yeon Lee, Eun Lee, Yoon Mee Park, Soo-Jong Hong Abstract The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). […]

Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression

Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression

Mi Nam Lee, Hee-Su Hwang, Sin-Hye Oh, Amir Roshanzadeh, Jung-Woo Kim, Ju Han Song, Eung-Sam Kim and Jeong-Tae Koh Abstract Supplementation of mesenchymal stem cells (MSCs) at sites of bone resorption is required for bone homeostasis because of the non-proliferation and short lifespan properties of the osteoblasts. Calcium ions (Ca 2+ ) are released from […]

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

Eun-Hee Cho, Keun-Hyok Cho, Hyang Ah Lee, and Sang-Wook Kim Abstract Osteopontin (OPN) is an acidic, noncollagenous matrix protein produced by the bone and kidneys. It is reportedly involved in bone resorption and formation. We examined the association between serum OPN levels and bone mineral density in postmenopausal women. Premenopausal women (n = 32) and […]

Calcium Signaling and Cardiac Arrhythmias

Calcium Signaling and Cardiac Arrhythmias

Andrew P. Landstrom, Dobromir Dobrev and Xander H.T. Wehrens Abstract There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca 2+ ) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, […]

Association between the gut microbiota and mineral metabolism

Association between the gut microbiota and mineral metabolism

Katarzyna Skrypnik and Joanna Suliburska Abstract The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals,andtheeffectofthisinteractiononthehealthofthehost.TheWebofSciencedatabasefromtheyears2013–2017on thistopicwasreviewed.Numerousinvitrostudieshaveshownthatironsignificantlyaffectstheintestinalmicrobiota.However, Bifidobacteriaceaearecapableofbindingironinthelargeintestine,therebylimitingtheformationoffreeradicalssynthesized inthepresenceofiron,andthusreducingtheriskofcolorectalcancer.Animalstudieshaverevealedthatsupplementationwith probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic interaction between microbiota and zinc was shown. Human […]

The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones

The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones

Anand Vaidya, MD MMSc, Jenifer M. Brown, MD, and Jonathan S. Williams, MD MMSc Abstract There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis while the latter is most often associated with skeletal health. […]

The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue

The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue

Ralf Brisch, Arthur Saniotis, RainerWolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Katharina Braun, Zbigniew Jankowski, Jaliya Kumaratilake, Maciej Henneberg and Tomasz Gos. Abstract Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia.The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent […]

Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]