Increasing Ionic Calcium Inhibits Myeloma Cell Growth and its Progression in Mouse. Syed Hassan Mehdi¹, Alex Lee², Paul K Lee², Donghoon Yoon¹ ¹ Myeloma Center, the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; ²CBHI (Calcium & Bone Health Institute, Canada), Coquitlam, British Colombia, Canada Multiple myeloma (MM) is the second most […]
Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass Context: Denosumab treatment for 24 months increased bone mineral density (BMD) and reduced bone turnover markers (BTM) in postmenopausal women. Objective: The aim was to determine the effects of prior denosumab or placebo injections […]
To evaluate the safety and efficacy of romosozumab in men with osteoporosis Context: Globally, one in five men aged.50 years is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming agents for men, new osteoporosis treatments are needed. Objective: To evaluate the safety and efficacy of […]
Calcium signaling in T cells Calcium (Ca2+) signaling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca2+ regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several […]
Cancer stem cell Why does cancer recur? Already in 1877, Virchow’s student Cohnheim noticed this cell population and pointed out that it possesses an embryonic character*. Today, those cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs) and are seen as drivers of tumor establishment and growth, often correlated to aggressive, heterogeneous and […]
SAC(Sigma Anti-bonding Calcium Carbonate) Study with GCaMP on Zebra Fish By Prof. Sandra Rieger, Sylvester Comprehensive Cancer Center, University of Miami, Jan. 2021 As shown in the following figure, D depicts the fluorescent cells which were analyzed. Zebrafish transient microinjections result was in a mosaic expression; therefore, only some cells expressed the GCaMP. A red […]
Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan,Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yong Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan & Kelvin Wai-Kwok Yeung Abstract Extrapulmonary complications of different organ systems have been increasingly recognized […]
JIHWAN SONG , Syed Hassan Mehdi, Sae Woong Oh, Jongsung Lee, Paul K Lee, Alex Lee, Yong Gu Lee, and Donghoon Yoon Abstract Sigma Anti-Bonding Molecule Calcium Carbonate (SAC) is a chemically modified calcium carbonate with a unique weak bonding structure that significantly increases the calcium absorbing rate in our body. It can influence environmental […]
Bo Abrahamsen, Clive Osmond and Cyrus Cooper Abstract Osteoporosis is a chronic disease, carrying an elevated risk of fractures, morbidity, and death. Long-term treatment may be required, but the long-term risks with osteoporosis drugs remain incompletely understood. The competing risk of death may be a barrier to treating the oldest, yet this may not be […]
Amanda Devine, R Arthur Criddle, Ian M Dick, Deborah A Kerr, and Richard L Prince Abstract The influence of urinary sodium excretion and dietary calcium intake was examined in a 2-y longitudinal study of bone density in 124 women postmenopausal for > 10 y. Analysis of bone density changes showed that urinary sodium excretion was […]