Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]
Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,* ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]
RJ DeBerardinis1,2 and T Cheng1 1 Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA and 2 McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA Several decades of research have sought to characterize tumor cell metabolism in the hope […]
Psoriasis and Altered Calcium Metabolism: Downregulated Capacitative Calcium Influx and Defective Calcium-Mediated Cell Signaling in Cultured Psoriatic Keratinocytes1 Seija-Liisa Karvonen,*2 Timo Korkiama ki,*2 Heli Yla -Outinen,* Marja Nissinen,* Harri Teerikangas,:j Kati Pummi,§ Jaakko Karvonen,t and Juha Peltonen* *Department of Anatomy and Cell Biology, tDepartment of Dermatology, and :jDepartment of Surgery, University of Oulu, Oulu, Finland; […]
: a comprehensive review Paolo E. Porporato, Suveera Dhup, Rajesh K. Dadhich, Tamara Copetti and Pierre Sonveaux * Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, University of Louvain Medical School, Brussels, Belgium Cancer is a metabolic disease and the solution of two metabolic equations: to produce energy with limited resources […]