The Role of Calcium in Inflammation-Associated Bone Resorption

The Role of Calcium in Inflammation-Associated Bone Resorption

Gordon L. Klein Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555-0165, USA; gklein@utmb.edu; Tel.: +1-409-747-5700; Fax: +1-409-770-6919 Received: 28 June 2018; Accepted: 27 July 2018; Published: 1 August 2018   Abstract: The aim of this mini-review is to discuss the role of calcium in the […]

Pharmacology of the calcium sensing receptor – Mini-Review

Summary Calcium sensing receptor (CASR) is a G-protein couple¬†receptor which plays a key role in calcium homeostasis in vertebrates. Its extracellular domain is sensitive to divalent cations, aminoacids and polyamines. In parathyroid glands, CASR activation causes parathyroid hormone (PTH) reduction and subsequently a decrease in blood calcium concentration. In PTH-dependent disorders, e.g. primary and secondary […]