This experimental report investigates the biological effects of SAC® in cellular models relevant to odontology and oral pathology, with a focus on human gingival fibroblasts and inflammation-related cellular responses.
The study evaluated SAC® under inflammatory stimulation using both macrophages and human gingival fibroblast (hGF-1) cells. Key biomarkers included inflammatory mediators such as IL-6, TNF-α, IL-1β, COX-2, and nitric oxide, together with matrix metalloproteinases MMP-1, MMP-3, and MMP-9.
Across the tested models, SAC® was associated with concentration-dependent decreases in multiple inflammatory and extracellular matrix-related markers, while cell viability was also evaluated across the experimental dilution range.
In human gingival fibroblast cells, SAC® was evaluated for its effects on factors involved in oral tissue homeostasis and extracellular matrix remodeling.
Under IL-1β-stimulated conditions, SAC® was associated with concentration-dependent decreases in MMP-1, MMP-3, and MMP-9 mRNA expression. These findings provide experimental insight into gingival fibroblast responses and extracellular matrix-related regulation in oral tissue.
The study also examined inflammatory responses in both LPS-stimulated macrophages and IL-1β-stimulated human gingival fibroblasts.
SAC® treatment was associated with reduced nitric oxide production and concentration-dependent decreases in IL-6, TNF-α, IL-1β, and COX-2 mRNA expression, providing laboratory evidence relevant to inflammatory processes within the oral tissue environment.
Review the full presentation covering SAC® research in gingival fibroblasts, macrophage activation, inflammatory biomarkers, cell viability, and extracellular matrix-related MMP expression.
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