CBHI News & Innovation

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Calcium Signaling and Cardiac Arrhythmias

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Calcium Signaling and Cardiac Arrhythmias

Andrew P. Landstrom, Dobromir Dobrev and Xander H.T. Wehrens Abstract There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca 2+ ) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, […]

Association between the gut microbiota and mineral metabolism

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Association between the gut microbiota and mineral metabolism

Katarzyna Skrypnik and Joanna Suliburska Abstract The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals,andtheeffectofthisinteractiononthehealthofthehost.TheWebofSciencedatabasefromtheyears2013–2017on thistopicwasreviewed.Numerousinvitrostudieshaveshownthatironsignificantlyaffectstheintestinalmicrobiota.However, Bifidobacteriaceaearecapableofbindingironinthelargeintestine,therebylimitingtheformationoffreeradicalssynthesized inthepresenceofiron,andthusreducingtheriskofcolorectalcancer.Animalstudieshaverevealedthatsupplementationwith probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic interaction between microbiota and zinc was shown. Human […]

The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones

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The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones

Anand Vaidya, MD MMSc, Jenifer M. Brown, MD, and Jonathan S. Williams, MD MMSc Abstract There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis while the latter is most often associated with skeletal health. […]

Serum triglyceride concentrations and cancer risk in a large cohort study in Austria

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Serum triglyceride concentrations and cancer risk in a large cohort study in Austria

H Ulmer, W Borena, K Rapp, J Klenk, A Strasak, G Diem, H Concin and G Nagel, VHM & PP Study Group Obesity has been identified as a major risk factor for such cancer sites as colon, renal, breast, and endometrium (Bianchini et al, 2002; Calle and Kaaks, 2004; Rapp et al, 2005), whereas hypertriglyceridemia […]