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Altered calcium signaling in cancer cells

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Altered calcium signaling in cancer cells

Teneale A. Stewart, Kunsala T.D.S. Yapa, Gregory R. Monteith Abstract It is the nature of the calcium signal, as determined by the coordinated activity of a suite of calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell’s fate. Deregulation of the calcium signal is often deleterious and has been linked to each […]

The importance of Ca2+ -dependent mechanisms for the initiation of the heartbeat

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The importance of Ca<sup>2+</sup> -dependent mechanisms for the initiation of the heartbeat

Rebecca A. Capel and Derek A. Terrar* British Heart Foundation Centre of Research Excellence, Department of Pharmacology, University of Oxford, Oxford, UK   Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of […]

Manipulating extracellular tumour pH: an effective target for cancer therapy

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Manipulating extracellular tumour pH: an effective target for cancer therapy

Guanyu Hao, Zhi Ping Xu* and Li Li *   Abstract

Acidic pH: the weakness of cancer cells

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Acidic pH: the weakness of cancer cells

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.