Innovation & Break through Technology

Articles

The importance of Ca2+ -dependent mechanisms for the initiation of the heartbeat

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The importance of Ca<sup>2+</sup> -dependent mechanisms for the initiation of the heartbeat

Rebecca A. Capel and Derek A. Terrar* British Heart Foundation Centre of Research Excellence, Department of Pharmacology, University of Oxford, Oxford, UK   Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of […]

Manipulating extracellular tumour pH: an effective target for cancer therapy

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Manipulating extracellular tumour pH: an effective target for cancer therapy

Guanyu Hao, Zhi Ping Xu* and Li Li *   Abstract

Acidic pH: the weakness of cancer cells

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Acidic pH: the weakness of cancer cells

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

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Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,*   ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]

The Role of Calcium in Inflammation-Associated Bone Resorption

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The Role of Calcium in Inflammation-Associated Bone Resorption

Gordon L. Klein Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555-0165, USA; gklein@utmb.edu; Tel.: +1-409-747-5700; Fax: +1-409-770-6919 Received: 28 June 2018; Accepted: 27 July 2018; Published: 1 August 2018   Abstract: The aim of this mini-review is to discuss the role of calcium in the […]

Viral Membrane Channels: Role and Function in the Virus Life Cycle

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Viral Membrane Channels: Role and Function in the Virus Life Cycle

ChingWooen Sze 1 and Yee-Joo Tan 1;2;* 1 Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, MD4, Level 3, 5 Science Drive 2, Singapore 117597, Singapore; E-Mail: micscw@nus.edu.sg 2 Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A * STAR), Singapore […]