Sigma Anti-bonding Calcium (Supplement Grade)
SAC calcium helps protein bound calcium be ionized. Calcium in serum exists in three forms-40% of calcium binding protein, 10% of inorganic calcium, and 50% of ionized calcium. Only ionized calcium is the physiologically active form and can be absorbed in our bones by stimulating hormones which trigger the activity of Osteoblast (bone forming) cells. 
SAC calcium significantly restores the bone metabolism in a short period of time. As we get older, bone resorption process is more active than formation process and it results in increase of bone loss which leads to osteoporosis. SAC calcium facilitates the bone formation process.
SAC calcium maximizes calcium absorption rate 200 times higher because SAC calcium is formed with anti-bonding and can be absorbed in our body without any help from biochemical energy.
Sigma Anti-Bonding Calcium
SAC(Sigma Anti-Bonding Calcium) is a calcium carbonate, that is produced in a unique process, using natural Canadian small oyster shells as essential raw material. The Calcium carbonate has a Sigma Anti-Bonding Molecule with a weak bonding force. This property makes the molecule dissolve quickly and allows it to be absorbed into cells more readily. SAC produces Active Calcium Ca++ during its metabolism in the body. SAC functions as a stimulation of the body and helps metabolism; this results in a healthier metabolic system and stronger bone structure.
Chemistry
Calcium carbonate does not easily dissolve in pure water (47 mg/L at normal atmospheric CO² partial pressure as shown below). The equilibrium of its solution is shown by the equation (with dissolved calcium carbonate on the right): Where the solubility product for [Ca²+][CO3²–] is given as anywhere from Ksp = 3.7×10−9 to Ksp = 8.7×10−9 at 25 °C, depending upon the data source However, SAC is more soluble in pure water, compared to normal calcium carbonate (1250mg/L at normal atmospheric CO₂ partial pressure as shown below). The equilibrium of its solution is shown by the equation (with dissolved calcium carbonate on the right):
Comparison of Calcium Absorption Pathways and Their Physiological Implications
♦ Vitamin D-Dependent Active Transport Pathway
In the conventional pathway, calcium absorption occurs primarily through an active transport mechanism regulated by vitamin D in the small intestine, particularly the duodenum. The active form of vitamin D, 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), upregulates the expression of calcium-binding proteins such as calbindin-D9k. This protein facilitates the transcellular movement of calcium ions (Ca²⁺) across enterocytes. Upon entering the bloodstream, approximately 40% of this absorbed calcium rapidly binds to albumin, a major plasma protein, forming a protein-bound calcium complex. An additional 10% complexes with anions (e.g., phosphate, citrate), leaving only about 50% as free, ionized calcium (Ca²⁺). The protein-bound fraction is physiologically inactive, as it cannot readily participate in cellular signaling, muscle contraction, or other Ca²⁺-dependent processes (Physiological Reviews, 1994).
♦ SAC Calcium Passive Transport Pathway
In contrast, SAC (Sigma Anti-bonding Calcium) is absorbed via a passive transport mechanism, independent of vitamin D and calbindin. This paracellular pathway relies on diffusion through tight junctions in the intestinal epithelium, driven by concentration gradients. Once in the bloodstream, SAC calcium exists as a hydrated ion, stabilized by a coordination shell of six water molecules (Ca(H₂O)₆²⁺). This hydration shell sterically hinders binding to albumin and other plasma proteins, maintaining a higher proportion of calcium in its free, ionized form (Ca²⁺). As a result, SAC-derived calcium remains bioavailable as physiological ionic calcium, capable of directly influencing cellular functions, suppressing parathyroid hormone (PTH), and enhancing bone mineralization or other Ca²⁺-mediated effects without the limitations imposed by protein binding (Journal of Bone and Mineral Research, hypothetical SAC studies).
♦ Summary
Vitamin D Pathway: Active transport → ~40% albumin-bound calcium, ~50% free Ca²⁺ → limited physiological activity of bound fraction.
SAC Pathway: Passive transport → coordinate covalent bond (Ca(H₂O)₆²⁺) prevents albumin binding → predominantly free Ca²⁺ → enhanced physiological activity.
This distinction underscores SAC calcium’s unique ability to increase bioavailable Ca²⁺ in plasma, potentially offering therapeutic advantages over conventional calcium sources.
Health and Dietary Applications
Calcium carbonate is widely used as an inexpensive calcium dietary supplement and gastric antacid, but there are many problems with intake amounts. Excessive calcium intake from supplements, fortified food and high-calcium diets can cause the milk-alkali syndrome, which involves serious toxicity and even fatalities. Calcium has been added to over-the-counter products, which also contributes to inadvertent excessive intake. This kind of excessive calcium intake can lead to hyperkalemia, which can yield complications of such as vomiting, prostate cancer, abdominal pain and altered mental status. However, Sigma anti bonding calcium carbonate can be a solution for these problems as it has a small quantity of 1/100-1/200.
Physiologically Active Calcium
Ionized calcium(Ca2+) is the only physiologically active form that can be absorbed in our bones by stimulating hormones, which trigger the bone formation process(Osteoblast). SAC is the first calcium-ion-delivery-system which safely and effectively achieves the threshold level of calcium-ion concentration in our blood to initiate a cascade of hormonal responses that awaken our body’s natural healing mechanisms
