This report presents experimental research conducted by the Department of Pharmaceutical Biochemistry at Kyung Hee University, investigating the biological effects of SAC^® in cellular models relevant to oral tissue health and extracellular matrix (ECM) regulation.

The study evaluated the influence of SAC^® on inflammatory responses in both macrophages and human gingival fibroblasts under stimulated conditions. Key biomarkers associated with inflammation, including IL-6, TNF-α, IL-1β, and COX-2, were analyzed alongside matrix metalloproteinases (MMP-1, MMP-3, and MMP-9), which play important roles in ECM remodeling and tissue homeostasis.

Across multiple experimental models, SAC^® demonstrated concentration-dependent modulation of inflammatory mediators and ECM-related factors while maintaining favorable cellular viability under most test conditions. These findings provide scientific insight into the potential relationship between SAC^®, inflammatory regulation, and the maintenance of healthy oral tissue microenvironments.

The complete report is available below for review.