So-Yeon Lee, Eun Lee, Yoon Mee Park, Soo-Jong Hong
The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the
skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis
(AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating
skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and
skin microbiome could be manipulated to treat AD.