• ISACS 2019

    2019 International SAC Symposium

  • world without Osteoporosis and Calcium related disease

    Our mission is to achieve this vision through excellence research and clinical trial

  • Cutting-edge Translational Clinical Research

    Clinical data from research within Clacium related critical illness

  • Sigma Anti-Bonding Calcium

    Sigma Anti-Bonding Calcium Formulation Technology

  • More Research & Developement

    Revolutionary technology related with ware-able device and skin patched device.- With SFU (Simon Fraser Univ.)

Innovation & Break through Technology

Articles

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Aug 16, 2019 | No Comments
Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1    Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico   Abstract   Autism is a severe developmental disorder, whose pathogenetic underpinnings are […]

Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways

Aug 16, 2019 | No Comments
Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways

Biochimica et Biophysica Acta (BBA) – Molecular Cell Research Volume 1865, Issue 11, Part B, November 2018, Pages 1718-1732 Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways☆ Author links open overlay panelRachel L.NguyenabYuliya V.MedvedevaabdTejasvi E.AyyagariabGalinaSchmunkbJohn JayGargusabc a Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA b […]

Interleukin-1beta Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin*

Aug 16, 2019 | No Comments
Interleukin-1beta Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin*

Interleukin-1 Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin*   Joseph S. Ainscough‡1, G. Frank Gerberick§, Ian Kimber‡, and Rebecca J. Dearman‡ From the ‡ Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and the § Procter & Gamble Co. , Cincinnati, Ohio 45253   The secretion of IL-1 is […]

Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study

Aug 16, 2019 | No Comments
Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study

Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study Jacquelaine Bartlett, MS,#1 Irene M. Predazzi, PhD,#2 Scott M. Williams, PhD,1 William S. Bush, PhD, MS,3Yeunjung Kim, MD, MPH,4 Stephen Havas, MD, MPH, MS,5 Peter P. Toth, MD, PhD,6 Sergio Fazio, MD, PhD,2 andMichael Miller, MD7     Abstract Background— While the inverse association between high-density lipoprotein […]

HDL cholesterol and bone mineral density: Is there a genetic link?

Aug 16, 2019 | No Comments
HDL cholesterol and bone mineral density: Is there a genetic link?

HDL cholesterol and bone mineral density: Is there a genetic link? Cheryl L. Ackert-Bicknell   Abstract Overwhelming evidence has linked cardiovascular disease and osteoporosis, but the shared root cause of these two diseases of the elderly remains unknown. Low levels of high-density lipoprotein cholesterol (HDL) and bone mineral density (BMD) are risk factors for cardiovascular […]

Cancer-Related Hypercalcemia

Aug 7, 2019 | No Comments
Cancer-Related Hypercalcemia

University of Nebraska Medical Center, Omaha, NE Abstract Hypercalcemia has been reported to occur in up to30%of patients whohave a malignancy. Hypercalcemia is most common in those who have later-stage malignancies and predicts a poor prognosis for those with it. The most common causes include humoral hypercalcemia of malignancy mediated by parathyroid hormone–related peptide, osteolytic […]