• ISACS 2019

    2019 International SAC Symposium

  • world without Osteoporosis and Calcium related disease

    Our mission is to achieve this vision through excellence research and clinical trial

  • Cutting-edge Translational Clinical Research

    Clinical data from research within Calcium related critical illness

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    Sigma Anti-Bonding Calcium Formulation Technology

  • More Research & Developement

    Revolutionary technology related with ware-able device and skin patched device.- With SFU (Simon Fraser Univ.)

Innovation & Break through Technology

Articles

Risk of High Dietary Calcium for Arterial Calcification in Older Adults -Review

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Risk of High Dietary Calcium for Arterial Calcification in Older Adults -Review

Nutrients 2013, 5, 3964-3974; doi:10.3390 / nu5103964 / ISSN 2072-6643 Abstract:   Concern has recently arisen about the potential adverse effects of excessive calcium intakes, i.e., calcium loading from supplements, on arterial calcification and risks of cardiovascular diseases (CVD) in older adults. Published reports that high calcium intakes in free-living adults have relatively little or […]

Chronic Iron Deficiency as an Emerging Risk Factor for Osteoporosis: A Hypothesis (Review)

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Chronic Iron Deficiency as an Emerging Risk Factor for Osteoporosis: A Hypothesis (Review)

Chronic Iron Deficiency as an Emerging Risk Factor for Osteoporosis: A Hypothesis (Review) Laura Toxqui and M. Pilar Vaquero * Abstract: Iron is essential in oxygen transport and participates in many enzymatic systems in the body, with important roles in collagen synthesis and vitamin D metabolism. The relationship between iron and bone health comes from […]

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

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Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1    Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico   Abstract   Autism is a severe developmental disorder, whose pathogenetic underpinnings are […]

Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways

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Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways

Biochimica et Biophysica Acta (BBA) – Molecular Cell Research Volume 1865, Issue 11, Part B, November 2018, Pages 1718-1732 Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways☆ Author links open overlay panelRachel L.NguyenabYuliya V.MedvedevaabdTejasvi E.AyyagariabGalinaSchmunkbJohn JayGargusabc a Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA b […]

Interleukin-1beta Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin*

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Interleukin-1beta Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin*

Interleukin-1 Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin*   Joseph S. Ainscough‡1, G. Frank Gerberick§, Ian Kimber‡, and Rebecca J. Dearman‡ From the ‡ Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and the § Procter & Gamble Co. , Cincinnati, Ohio 45253   The secretion of IL-1 is […]

Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study

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Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study

Is Isolated Low HDL-C a CVD Risk Factor?: New Insights from the Framingham Offspring Study Jacquelaine Bartlett, MS,#1 Irene M. Predazzi, PhD,#2 Scott M. Williams, PhD,1 William S. Bush, PhD, MS,3Yeunjung Kim, MD, MPH,4 Stephen Havas, MD, MPH, MS,5 Peter P. Toth, MD, PhD,6 Sergio Fazio, MD, PhD,2 andMichael Miller, MD7     Abstract Background— While the inverse association between high-density lipoprotein […]