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Increasing Ionic Calcium Inhibits Myeloma Cell Growth and its Progression in Mouse

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Increasing Ionic Calcium Inhibits Myeloma Cell Growth and its Progression in Mouse

Increasing Ionic Calcium Inhibits Myeloma Cell Growth and its Progression in Mouse. Syed Hassan Mehdi¹, Alex Lee², Paul K Lee², Donghoon Yoon¹ ¹ Myeloma Center, the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; ²CBHI (Calcium & Bone Health Institute, Canada), Coquitlam, British Colombia, Canada Multiple myeloma (MM) is the second most […]

Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass

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Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass

Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass Context: Denosumab treatment for 24 months increased bone mineral density (BMD) and reduced bone turnover markers (BTM) in postmenopausal women. Objective: The aim was to determine the effects of prior denosumab or placebo injections […]

To evaluate the safety and efficacy of romosozumab in men with osteoporosis

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To evaluate the safety and efficacy of romosozumab in men with osteoporosis

To evaluate the safety and efficacy of romosozumab in men with osteoporosis Context: Globally, one in five men aged.50 years is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming agents for men, new osteoporosis treatments are needed. Objective: To evaluate the safety and efficacy of […]

Calcium signalling in T cells

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Calcium signalling in T cells

Calcium signaling in T cells Calcium (Ca2+) signaling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca2+ regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several […]