Association between the gut microbiota and mineral metabolism

Association between the gut microbiota and mineral metabolismc 2
Katarzyna Skrypnik and Joanna Suliburska

Abstract

The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and
minerals,andtheeffectofthisinteractiononthehealthofthehost.TheWebofSciencedatabasefromtheyears2013–2017on
thistopicwasreviewed.Numerousinvitrostudieshaveshownthatironsignificantlyaffectstheintestinalmicrobiota.However,
Bifidobacteriaceaearecapableofbindingironinthelargeintestine,therebylimitingtheformationoffreeradicalssynthesized
inthepresenceofiron,andthusreducingtheriskofcolorectalcancer.Animalstudieshaverevealedthatsupplementationwith
probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic
interaction between microbiota and zinc was shown. Human studies have provided evidence of the influence of probiotic
bacteria on parathormone, calcium and phosphate levels and thus on bone resorption. Recent studies have produced new
informationmainlyontheimpactoftheintestinalbacteriaonthemetabolismofcalciumandiron.Fromascientificperspective,
the most urgent fields that remain to be investigated are the identification of all human gut microbes and new therapies
targeting the interaction between intestinal bacteria and minerals.

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