Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells

Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells

Young-Kyoung Lee#, Eui-Yeun Yi#, Shi-Young Park, Won-Jun Jang, Yu-Seon Han, Myeong-Eun Jegal & Yung-Jin Kim* Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Korea Mitochondrial DNA (mtDNA) mutations are often observed in various cancer types. Although the correlation between mitochondrial dysfunction and cancer malignancy has been demonstrated by several studies, […]

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

Carlotta Giorgi1,, Massimo Bonora1,, Sonia Missiroli1, Federica Poletti1, Fabian Galindo Ramirez2,3, Giampaolo Morciano1, Claudia Morganti1, Pier Paolo Pandolfi4,Fabio Mammano2 and Paolo Pinton1 1 Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biologyand LTTA center, University of Ferrara, Ferrara, Italy 2 Department of Physics and Astronomy, University of Padua, and Venetian […]