Lactate: Mirror and Motor of Tumor Malignancy

Stefan Walenta and Wolfgang F. Mueller-Klieser   A number of studies have shown that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular  excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagnosis of the disease, we […]