Study of SAC Roles in Multiple Myeloma
& Erythropoietin-Induced Osteoporosis

Study of SAC Roles in Multiple Myeloma <br> & Erythropoietin-Induced Osteoporosis

Collaborative Research with UAMS

Investigator of UAMS Investigator of CBHI:
Donghoon Yoon, PhD
University of Arkansas for Medical Sciences
Winthrop P.Rokerfeller Cancer Institute
4301 W. Markham St., Slot #776
Winthrop Cancer Center, Room #408
Little Rock, AR 72205
Paul Lee, PhD
Calcium & Bone Health Institute
#112 16 Fawcett Road.
Coquitlam, BC. V3K6X9

Multiple myeloma (MM) is the second most common hematological malignancy. It mostly occurs at older ages and remains an incurable disease. MM is a B cell cancer mainly characterized by the proliferation of malignant plasma cells in the bone marrow, the presence of monoclonal serum immunoglobulin, and the occurrence of osteolytic lesions. MM is highly associated with bone destruction. Osteoclasts (OCS) were shown to enhance bone destruction and support myeloma progression while osteoblasts (OBs) were shown to enhance bone formation and inhibit myeloma growth. In MM the activities of OCS were up-regulated while the 0B activity was down-regulated. This evidence suggested that manipulating activities of OCS and/or OBs can be a good candidate for a novel myeloma therapy.

According to company website, Sigma Anti-bonding Calcium (SAC) is highly soluble in water and increased up to 80% bone mineral density. SAC is the first ionized calcium that can be delivered into the body and deposited into the bone. In myeloma patients, during the first bortezomib treatment cycle, serial serum parathyroid hormone (PTH) measurements revealed a significant difference in responders from non-responder group against bortezomib. However, the nonresponder group showed PTH release when Panobinostat with Bortezomib was injected. Extracellular calcium levels regulate PTH release, thereby controlling serum calcium levels systematically. PTH may induce bone resorption via osteoclasts. Our recent report demonstrated that PTH axis plays important role in anti-MM activity. We recently found the thymus derived PTH and parathyroidectomized (PTX) mice do not develop MM after 5TGM1 injection. After PTX mouse recovered the serum calcium immediately. We strongly believe that PTH has important role in anti-myeloma activity via uncovered mechanism. These uncovered mechanisms may include ionized calcium that can be introduced by SAC.

– Study of SAC’s Role in Multiple Myeloma and Erythropoietin-Induced Osteoporosis.
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