Regulation of calcium signaling in lung cancer

Haihong Yang, Qi Zhang, Jianxing He, Wenju Lu

State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, PR China


Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous cellular signal, which is crucial in cancer. This review presents regulation of calcium signaling in lung cancer. Altered expression of specific Ca2+ channels and Ca2+-binding proteins are characterizing features of lung cancer, which regulate cell signaling pathway leading to cell proliferation or apoptosis. Chemoresistance is frequent in lung cancer. Altered endoplasmic reticulum Ca2+ homeostasis of lung cancer cell is correlated with drug resistance. Hypoxia has a vital role in tumor angiogenesis, metastasis, apoptosis. And Ca2+ channels are open induced by hypoxia with the increase of Ca2+ influx causing tumor growth.


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