Rebecca A. Capel and Derek A. Terrar* British Heart Foundation Centre of Research Excellence, Department of Pharmacology, University of Oxford, Oxford, UK Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of […]
Guanyu Hao, Zhi Ping Xu* and Li Li * Abstract
A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.
Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,* ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]
Gordon L. Klein Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555-0165, USA; gklein@utmb.edu; Tel.: +1-409-747-5700; Fax: +1-409-770-6919 Received: 28 June 2018; Accepted: 27 July 2018; Published: 1 August 2018 Abstract: The aim of this mini-review is to discuss the role of calcium in the […]
ChingWooen Sze 1 and Yee-Joo Tan 1;2;* 1 Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, MD4, Level 3, 5 Science Drive 2, Singapore 117597, Singapore; E-Mail: micscw@nus.edu.sg 2 Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A * STAR), Singapore […]
Xingjuan Chen 1,2, Ruiyuan Cao 2,* and Wu Zhong 2,* 1 Institute of Medical Research, Northwestern Polytechnical University, Xi’an 710072, China; xjchen@nwpu.edu.cn 2 National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China * Correspondence: 21cc@163.com (R.C.); zhongwu@bmi.ac.cn (W.Z.) Received: 11 December 2019; Accepted: 24 December 2019; Published: […]
Yubin Zhoua, Teryl K. Freyb,*, and Jenny J. Yanga,** aDepartment of Chemistry, Georgia State University, 50 Decatur St., Atlanta, GA 30303 USA bDepartment of Biology, Georgia State University, 50 Decatur St., Atlanta, GA 30303 USA Abstract Ca2+ is one of the most universal and versatile signalling molecules and is involved in almost every aspect […]
Alice H. Tischler, Louise Lie, Cecilia M. Thompson, Karen L. Visick George O’Toole, Editor ABSTRACT Vibrio fischeri uses biofilm formation to promote symbiotic colonization of its squid host, Euprymna scolopes. Control over biofilm formation is exerted at the level of transcription of the symbiosis polysaccharide (syp) locus by a complex set of two-component regulators. Biofilm formation can be induced […]
Vineet D. Menachery1, Boyd L. Yount Jr1, Kari Debbink1,2, Sudhakar Agnihothram3, Lisa E. Gralinski1, Jessica A. Plante1, Rachel L. Graham1, Trevor Scobey1, Xing-Yi Ge8, Eric F. Donaldson1, Scott H. Randell4,5, Antonio Lanzavecchia6, Wayne A. Marasco7, Zhengli-Li Shi8, and Ralph S. Baric1, Abstract The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East […]