The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones

The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones

Anand Vaidya, MD MMSc, Jenifer M. Brown, MD, and Jonathan S. Williams, MD MMSc Abstract There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis while the latter is most often associated with skeletal health. […]

The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue

The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue

Ralf Brisch, Arthur Saniotis, RainerWolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Katharina Braun, Zbigniew Jankowski, Jaliya Kumaratilake, Maciej Henneberg and Tomasz Gos. Abstract Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia.The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent […]

Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Cancer cell behaviors mediated by dysregulated pH dynamicsat a glance

Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]

The importance of Ca2+ dependent mechanisms for the initiation of the heartbeat

The importance of Ca<sup>2+</sup> dependent mechanisms for the initiation of the heartbeat

Rebecca A. Capel and Derek A. Terrar Abstract Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of calcium from the sarcoplasmic reticulum (SR) (“calcium clock”). Here we discuss recent evidence on mechanisms […]

Altered calcium signaling in cancer cells

Altered calcium signaling in cancer cells

Teneale A. Stewart, Kunsala T.D.S. Yapa, Gregory R. Monteith Abstract It is the nature of the calcium signal, as determined by the coordinated activity of a suite of calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell’s fate. Deregulation of the calcium signal is often deleterious and has been linked to each […]

The importance of Ca2+ -dependent mechanisms for the initiation of the heartbeat

The importance of Ca<sup>2+</sup> -dependent mechanisms for the initiation of the heartbeat

Rebecca A. Capel and Derek A. Terrar* British Heart Foundation Centre of Research Excellence, Department of Pharmacology, University of Oxford, Oxford, UK   Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of […]

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,*   ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]