Increasing Ionic Calcium Inhibits Myeloma Cell Growth and its Progression in Mouse. Syed Hassan Mehdi¹, Alex Lee², Paul K Lee², Donghoon Yoon¹ ¹ Myeloma Center, the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; ²CBHI (Calcium & Bone Health Institute, Canada), Coquitlam, British Colombia, Canada Multiple myeloma (MM) is the second most […]
Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass Context: Denosumab treatment for 24 months increased bone mineral density (BMD) and reduced bone turnover markers (BTM) in postmenopausal women. Objective: The aim was to determine the effects of prior denosumab or placebo injections […]
To evaluate the safety and efficacy of romosozumab in men with osteoporosis Context: Globally, one in five men aged.50 years is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming agents for men, new osteoporosis treatments are needed. Objective: To evaluate the safety and efficacy of […]
Calcium signaling in T cells Calcium (Ca2+) signaling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca2+ regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several […]
Cancer stem cell Why does cancer recur? Already in 1877, Virchow’s student Cohnheim noticed this cell population and pointed out that it possesses an embryonic character*. Today, those cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs) and are seen as drivers of tumor establishment and growth, often correlated to aggressive, heterogeneous and […]
SAC(Sigma Anti-bonding Calcium Carbonate) Study with GCaMP on Zebra Fish By Prof. Sandra Rieger, Sylvester Comprehensive Cancer Center, University of Miami, Jan. 2021 As shown in the following figure, D depicts the fluorescent cells which were analyzed. Zebrafish transient microinjections result was in a mosaic expression; therefore, only some cells expressed the GCaMP. A red […]