H Ulmer, W Borena, K Rapp, J Klenk, A Strasak, G Diem, H Concin and G Nagel, VHM & PP Study Group Obesity has been identified as a major risk factor for such cancer sites as colon, renal, breast, and endometrium (Bianchini et al, 2002; Calle and Kaaks, 2004; Rapp et al, 2005), whereas hypertriglyceridemia […]
Ralf Brisch, Arthur Saniotis, RainerWolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Katharina Braun, Zbigniew Jankowski, Jaliya Kumaratilake, Maciej Henneberg and Tomasz Gos. Abstract Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia.The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent […]
Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]
Rebecca A. Capel and Derek A. Terrar Abstract Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of calcium from the sarcoplasmic reticulum (SR) (“calcium clock”). Here we discuss recent evidence on mechanisms […]
Teneale A. Stewart, Kunsala T.D.S. Yapa, Gregory R. Monteith Abstract It is the nature of the calcium signal, as determined by the coordinated activity of a suite of calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell’s fate. Deregulation of the calcium signal is often deleterious and has been linked to each […]
Rebecca A. Capel and Derek A. Terrar* British Heart Foundation Centre of Research Excellence, Department of Pharmacology, University of Oxford, Oxford, UK Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of […]
Guanyu Hao, Zhi Ping Xu* and Li Li * Abstract
A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.
Katharine A. White1, Bree K. Grillo-Hill2 and Diane L. Barber1,* ABSTRACT Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including […]
Gordon L. Klein Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555-0165, USA; gklein@utmb.edu; Tel.: +1-409-747-5700; Fax: +1-409-770-6919 Received: 28 June 2018; Accepted: 27 July 2018; Published: 1 August 2018 Abstract: The aim of this mini-review is to discuss the role of calcium in the […]