Tag Archives: mitochondria

Abstract 12435: Mitochondrial Calcium Flux Modulates Pacemaker Activity in Embryonic Stem Cell-Derived Cardiomyocytes

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Abstract 12435: Mitochondrial Calcium Flux Modulates Pacemaker Activity in Embryonic Stem Cell-Derived Cardiomyocytes

ARRHYTHMIAS AND ELECTROPHYSIOLOGY SESSION TITLE: ARRHYTHMIAS IN EXPERIMENTAL MODELS II   An Xie, Anyu Zhou, Hong Liu, Guangbin Shi, Kenneth R Boheler, Samuel C Dudley Circulation. 2015;132:A12435   Abstract   Introduction: Ca2+ release from the sarcoplasmic reticulum (SR) is known to contribute to spontaneous activity via the cytoplasmic Na+-Ca2+ exchanger (NCX). Mitochondria are known to participate in Ca2+ cycling. We studied the […]

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The molecular era of the mitochondrial calcium uniporter

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Kimberli J. Kamer1,2 and Vamsi K. Mootha2–4   Abstract | The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its biophysical properties and relevance to cell death, bioenergetics and signaling have been investigated for decades. However, the genes encoding this channel have only recently been discovered, opening up a new ‘molecular era’ in the […]

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