So-Yeon Lee, Eun Lee, Yoon Mee Park, Soo-Jong Hong Abstract The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). […]
Mi Nam Lee, Hee-Su Hwang, Sin-Hye Oh, Amir Roshanzadeh, Jung-Woo Kim, Ju Han Song, Eung-Sam Kim and Jeong-Tae Koh Abstract Supplementation of mesenchymal stem cells (MSCs) at sites of bone resorption is required for bone homeostasis because of the non-proliferation and short lifespan properties of the osteoblasts. Calcium ions (Ca 2+ ) are released from […]
Eun-Hee Cho, Keun-Hyok Cho, Hyang Ah Lee, and Sang-Wook Kim Abstract Osteopontin (OPN) is an acidic, noncollagenous matrix protein produced by the bone and kidneys. It is reportedly involved in bone resorption and formation. We examined the association between serum OPN levels and bone mineral density in postmenopausal women. Premenopausal women (n = 32) and […]
Andrew P. Landstrom, Dobromir Dobrev and Xander H.T. Wehrens Abstract There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca 2+ ) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, […]
Katarzyna Skrypnik and Joanna Suliburska Abstract The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals,andtheeffectofthisinteractiononthehealthofthehost.TheWebofSciencedatabasefromtheyears2013–2017on thistopicwasreviewed.Numerousinvitrostudieshaveshownthatironsignificantlyaffectstheintestinalmicrobiota.However, Bifidobacteriaceaearecapableofbindingironinthelargeintestine,therebylimitingtheformationoffreeradicalssynthesized inthepresenceofiron,andthusreducingtheriskofcolorectalcancer.Animalstudieshaverevealedthatsupplementationwith probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic interaction between microbiota and zinc was shown. Human […]
Anand Vaidya, MD MMSc, Jenifer M. Brown, MD, and Jonathan S. Williams, MD MMSc Abstract There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis while the latter is most often associated with skeletal health. […]
H Ulmer, W Borena, K Rapp, J Klenk, A Strasak, G Diem, H Concin and G Nagel, VHM & PP Study Group Obesity has been identified as a major risk factor for such cancer sites as colon, renal, breast, and endometrium (Bianchini et al, 2002; Calle and Kaaks, 2004; Rapp et al, 2005), whereas hypertriglyceridemia […]
Ralf Brisch, Arthur Saniotis, RainerWolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Katharina Braun, Zbigniew Jankowski, Jaliya Kumaratilake, Maciej Henneberg and Tomasz Gos. Abstract Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia.The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent […]
Katharine A. White, Bree K. Grillo-Hill and Diane L. Barber Abstract Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH i ) and a decreased extracellular pH (pH e ) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer […]
Rebecca A. Capel and Derek A. Terrar Abstract Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (“membrane clock”) and others to uptake and release of calcium from the sarcoplasmic reticulum (SR) (“calcium clock”). Here we discuss recent evidence on mechanisms […]